Luteinizing hormone/choriogonadotropin receptor-mediated activation of heterotrimeric guanine nucleotide binding proteins in ovarian follicular membranes.

@article{RajagopalanGupta1998LuteinizingHR,
  title={Luteinizing hormone/choriogonadotropin receptor-mediated activation of heterotrimeric guanine nucleotide binding proteins in ovarian follicular membranes.},
  author={Rajsree M Rajagopalan-Gupta and Marilyn L. G. Lamm and Sutapa Mukherjee and Mark M. Rasenick and Mary E Hunzicker-Dunn},
  journal={Endocrinology},
  year={1998},
  volume={139 11},
  pages={
          4547-55
        }
}
The LH/CG receptor signals to adenylyl cyclase via the stimulatory heterotrimeric GTP binding regulatory protein, Gs, and to phospholipase C and potentially to other effectors, such as ion channels, via a G protein or proteins that have not been identified in gonadal cells. To identify G proteins activated in a physiological membrane environment upon LH/CG receptor activation, we used the ability of activated G proteins to bind GTP and incubated ovarian follicular membranes with the… CONTINUE READING

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