Lutein and zeaxanthin supplementation and association with visual function in age-related macular degeneration.

@article{Liu2014LuteinAZ,
  title={Lutein and zeaxanthin supplementation and association with visual function in age-related macular degeneration.},
  author={Rong Liu and Tian Wang and Bao Zhang and Li Qin and Changrui Wu and Qingshan Li and Le Ma},
  journal={Investigative ophthalmology \& visual science},
  year={2014},
  volume={56 1},
  pages={
          252-8
        }
}
PURPOSE To evaluate the effects of lutein and zeaxanthin on visual function in randomized controlled trials (RCTs) of AMD patients. METHODS Relevant studies were identified by searches on PubMed, EMBASE, Web of Science, and Cochrane Library database up to April 2014. Three investigators independently determined the eligibility of RCTs, which compared lutein and zeaxanthin intervention with placebo. The adjusted weighted mean differences (WMDs) from each study were extracted to calculate a… Expand
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Effect of lutein and zeaxanthin on macular pigment and visual function in patients with early age-related macular degeneration.
TLDR
Among patients with early AMD, supplementation with lutein and zeaxanthin improved macular pigment, which played a causative role in boosting visual function and might prevent the progression of AMD. Expand
Secondary outcomes in a clinical trial of carotenoids with coantioxidants versus placebo in early age-related macular degeneration.
TLDR
Functional and morphologic benefits were observed in key secondary outcomes after supplementation with L, Z, and coantioxidants in persons with early AMD. Expand
Randomized, double-blind, placebo-controlled study of zeaxanthin and visual function in patients with atrophic age-related macular degeneration: the Zeaxanthin and Visual Function Study (ZVF) FDA IND #78, 973.
TLDR
In older male patients with AMD, Zx-induced foveal MPOD elevation mirrored that of L and provided complementary distinct visual benefits by improving foveale cone-based visual parameters, whereas L enhanced those parameters associated with gross detailed rod-based vision, with considerable overlap between the 2 carotenoids. Expand
Effects of lutein supplementation on macular pigment optical density and visual acuity in patients with age-related macular degeneration.
TLDR
It is demonstrated that lutein supplementation increases macular pigment optical density, as assessed with an objective study, and indicates that patients who show a pronounced increase in MPOD also benefit in terms of visual function. Expand
Carotenoids in Age-Related Maculopathy Italian Study (CARMIS): Two-Year Results of a Randomized Study
TLDR
Patients treated with lutein/zeAXanthin and astaxanthin together with other nutrients were more likely to report clinically meaningful stabilization/improvements in VA, CS, and visual function through 24 months compared with nontreated subjects. Expand
Effect of lutein and antioxidant dietary supplementation on contrast sensitivity in age-related macular disease: a randomized controlled trial
TLDR
The results suggest that 6 mg of lutein supplementation in combination with other antioxidants is not beneficial for this group, and further work is required to establish optimum dosage levels. Expand
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TLDR
The statistically significant increase inmfERG latencies and the trend for reduced mfERG amplitudes on withdrawal are encouraging and may suggest a potentially beneficial effect of lutein-based supplementation in ARM-affected eyes. Expand
Lutein supplementation over a one-year period in early AMD might have a mild beneficial effect on visual acuity: the CLEAR study.
TLDR
L supplementation increases MPOD levels in early stage AMD patients, and according to the VA measurements, the progress of the disease might be slowed in some patients with augmented levels of MP. Expand
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TLDR
Treatment with this unique nutritional supplement increased VA above the expected baseline decrease in the majority of patients in this population with dry macular degeneration, and the results of the TOZAL study agree with the LAST and CARMIS studies and are predictive for positive visual acuity outcomes in the AREDS II trial. Expand
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TLDR
The supplementation of L, Z, O-3-LCPUFAs and antioxidants resulted in considerable increase in MPOD, which results in an improvement and stabilization in BCVA in AMD patients, and it is believed that the used supplementation with L and Z seems to reach a saturation level in retinal cell structure. Expand
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