Lutein, a nonprovitamin A, activates the retinoic acid receptor to induce HAS3-dependent hyaluronan synthesis in keratinocytes.

@article{Sayo2013LuteinAN,
  title={Lutein, a nonprovitamin A, activates the retinoic acid receptor to induce HAS3-dependent hyaluronan synthesis in keratinocytes.},
  author={Tetsuya Sayo and Yoshinori Sugiyama and Shintaro Inoue},
  journal={Bioscience, biotechnology, and biochemistry},
  year={2013},
  volume={77 6},
  pages={1282-6}
}
Carotenoids have been reported to have potent antioxidant activities and to protect tissues and cells from certain diseases and environmental insults. The molecular mechanism of the action of provitamin A carotenoids such as β-carotene and β-cryptoxanthin is mediated in part by retinoic acid, an active form of provitamin A, but the molecular basis of the biological activities of non-provitamin A carotenoids such as lutein, zeaxanthin, and astaxanthin is not fully understood. In this study, we… CONTINUE READING
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