Lutein, a Nonprovitamin A, Activates the Retinoic Acid Receptor to Induce HAS3-Dependent Hyaluronan Synthesis in Keratinocytes

@article{Sayo2013LuteinAN,
  title={Lutein, a Nonprovitamin A, Activates the Retinoic Acid Receptor to Induce HAS3-Dependent Hyaluronan Synthesis in Keratinocytes},
  author={Tetsuya Sayo and Yoshinori Sugiyama and Shintaro Inoue},
  journal={Bioscience, Biotechnology, and Biochemistry},
  year={2013},
  volume={77},
  pages={1282 - 1286}
}
Carotenoids have been reported to have potent antioxidant activities and to protect tissues and cells from certain diseases and environmental insults. The molecular mechanism of the action of provitamin A carotenoids such as β-carotene and β-cryptoxanthin is mediated in part by retinoic acid, an active form of provitamin A, but the molecular basis of the biological activities of non-provitamin A carotenoids such as lutein, zeaxanthin, and astaxanthin is not fully understood. In this study, we… 

A Combination of Soybean and Haematococcus Extract Alleviates Ultraviolet B-Induced Photoaging

SHM was found to inhibit wrinkle formation via the downregulation of matrix metalloproteinase (MMP)-1 mRNA and protein expression and this results highlight the potential for SHM to be developed as a therapeutic agent to prevent UVB-induced skin wrinkling.

Natural Astaxanthin Is a Green Antioxidant Able to Counteract Lipid Peroxidation and Ferroptotic Cell Death

A potential role for NAst in the prevention and co-treatment of chronic degenerative diseases by means of a sustainable approach is suggested, together with the "green sources" from which astaxanthin could derive.

Towards the mode of action of Strobilanthes crispus through integrated computational and experimental analyses

The findings suggest that lutein-RXRα interaction might play a role in the anti-breast cancer effects rendered by S. crispus.

Lutein Supplementation for Eye Diseases

Lutein is categorized as Generally Regarded as Safe (GRAS), posing minimal side-effects upon long term consumption, and its application and safety as a nutritional supplement and effects of lutein consumption on the aforementioned eye diseases will be reviewed.

Modulation of mitochondrial respiration underpins neuronal differentiation enhanced by lutein

It is suggested that lutein-stimulated neuronal differentiation is mediated by PI3K-dependent modulation of mitochondrial respiration and signaling, and that the consequential metabolic shifts initiate epigenetically dependent transcriptomic reprogramming in support of this morphogenesis.

1-Ethyl-β-N-acetylglucosaminide increases hyaluronan production in human keratinocytes by being converted to N-acetylglucosamine via β-N-acetylglucosaminidase-dependent manner.

Results suggest that β-NAG2 is converted to NAG by endogenous β- NAGase in keratinocytes, and the resulting NAG is further metabolized to UDP-NAg and utilized for HA production.

Structure-Function-Environment Relationship of the Isomers Zeaxanthin and Lutein

A synthesis is provided of the roles of the carotenoids zeaxanthin and/or lutein in opposing (i) photodamage in plants, (ii) photodamage to the human eye as well as cognitive dysfunction and a host

A Connecting Link between Hyaluronan Synthase 3-Mediated Hyaluronan Production and Epidermal Function

Results suggest that HAS3-mediated HA production, rather than extracellularly deposited HA, may play a role in keratinocyte proliferation and differentiation, at least in the developing epidermis in reconstructed epidermal equivalents.

Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with vitamin E

Overall, astaxanthin was more effective at both preventing and treating NASH compared with vitamin E in mice, and improved hepatic steatosis and tended to ameliorate the progression of NASH in biopsy-proven human subjects, suggesting that astxanthin might be a novel and promising treatment for NASH.

References

SHOWING 1-10 OF 45 REFERENCES

Synergistic Effect of N-Acetylglucosamine and Retinoids on Hyaluronan Production in Human Keratinocytes

It is found that N-acetylglucosamine (NAG) increased the production of HA by cultured keratinocytes dose dependently, but had no effect on the production by skin fibroblasts, suggesting that NAG is a new modulator of HA synthesis.

Provitamin A Function of Carotenoids: The Conversion of β-Carotene into Vitamin A

To remain viable as an alternative pathway of vitamin A formation from carotenoids in mammals, the excentric cleavage hypothesis clearly requires unambiguous direct supporting evidence.

Beta-carotene and lutein protect HepG2 human liver cells against oxidant-induced damage.

Carotenoid-loaded cells were partially or completely protected against oxidant-induced changes in lipid peroxidation, LDH release and amino acid and deoxyglucose transport.

Retinol-deficient rats can convert a pharmacological dose of astaxanthin to retinol: antioxidant potential of astaxanthin, lutein, and β-carotene.

It is confirmed that astaxanthin is converted into β-carotene and ROH in ROH-deficient rats, and the antioxidant potential of carotenoids was in the order astaxantha > lutein > β- carotene.

Suppression of mouse skin papilloma by canthaxanthin and beta-carotene in vivo: possibility of the regression of tumorigenesis by carotenoids without conversion to retinoic acid.

Oral administration of canthaxanthin or beta-carotene at 200 mg/kg/day for 14 days significantly reduced the cumulative size of papillomas induced on the skin by 9,10-dimethyl-1,2-benzanthracene after the accumulation of these carotenoids in the tumors.

Carotenoids enhance gap junctional communication and inhibit lipid peroxidation in C3H/10T1/2 cells: relationship to their cancer chemopreventive action.

Junctional communication appears to play an important role in cell growth control and carcinogenesis, and it is proposed that in this system carotenoid-enhanced intercellular communication provides a mechanistic basis for the cancer chemopreventive action ofcarotenoids.

Identification, Expression, and Substrate Specificity of a Mammalian β-Carotene 15,15′-Dioxygenase*

We have identified from mouse the first mammalian β-carotene 15,15′-dioxygenase (β-CD), a crucial enzyme in development and metabolism that governs the de novo entry of vitamin A from plant-derived

Molecular mechanisms of retinoid actions in skin

  • G. FisherJ. Voorhees
  • Biology, Medicine
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1996
This article will review recent findings in retinoid physiology and pharmacology and attempt to synthesize their meaning to provide a view into the mechanisms whereby retinoids participate in regulation of skin function.

Vitamin A and carotenoids as antioxidants in a physiological context.

  • J. Olson
  • Biology, Chemistry
    Journal of nutritional science and vitaminology
  • 1993
Vitamin A seems to be protected in vivo by other antioxidants and proteins rather than protecting other molecules, and carotenoids seem to act per se in such systems rather than by their conversion into vitamin A.