• Corpus ID: 14704010

Luteal phase bleeding after IVF cycles: comparison between progesterone vaginal gel and intramuscular progesterone and correlation with pregnancy outcomes

@article{Jabara2009LutealPB,
  title={Luteal phase bleeding after IVF cycles: comparison between progesterone vaginal gel and intramuscular progesterone and correlation with pregnancy outcomes},
  author={Sami I Jabara and Kurt T. Barnhart and Joan C Schertz and Pasquale Patrizio},
  journal={Journal of Experimental \& Clinical Assisted Reproduction},
  year={2009},
  volume={6}
}
BACKGROUND To compare luteal phase bleeding and pregnancy outcomes in normogonadotropic patients receiving progesterone vaginal gel (PVG) or intramuscular progesterone (IMP) injections. [] Key MethodMETHODS In this retrospective cohort study, data from 270 patients (292 cycles) undergoing day-3 fresh embryo transfer were analyzed. PVG, 90 mg daily (170 cycles) or IMP, 50 mg daily (122 cycles) began at egg retrieval.
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Tables from this paper

Adding Weekly Intramuscular Progesterone to a Twice Daily Vaginal Progesterone Capsule for Luteal Phase Support in IVF/ICSI Cycles Results in Similar Live Birth Rates
TLDR
The administration of weekly intramuscular progesterone in addition to twice-daily vaginal progester one capsule for luteal phase support post ART cycle does not result in higher live birth rate.
Vaginal bleeding in the luteal phase after IVF

References

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Bleeding patterns in women using intramuscular progesterone for luteal support in in-vitro fertilisation cycles
TLDR
The results suggest that i.m progesterone administration for luteal support in assisted reproduction cycles elongates lutenal phase in some patients due to supraphysiological serum progestersone levels, however, most patients start to bleed in the absence of pregnancy despite continued progester one treatment.
Analysis of the bleeding pattern in assisted reproduction cycles with luteal phase supplementation using vaginal micronized progesterone.
TLDR
The results reflect the normal bleeding pattern to be expected when vaginal progesterone is used for luteal support in IVF and embryo transfer, an approach whose efficacy has been amply proven.
Experience with progesterone gel for luteal support in a highly successful IVF programme.
TLDR
Crinone 8% offers an appreciable improvement, as it provides an effective luteal support option that avoids painful i.m. injections, and overall acceptability of Crinone 6% was excellent.
Intramuscular versus vaginal administration of progesterone for luteal phase support after in vitro fertilization and embryo transfer. A comparative randomized study.
TLDR
The ongoing pregnancy and the living birth rates per transfer were significantly higher in the patients supplemented with intramuscular P than in those treated with vaginal gel P.
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