Lustromycin, a new antibiotic produced by Streptomyces sp.

  title={Lustromycin, a new antibiotic produced by Streptomyces sp.},
  author={Hiroshi Tomoda and R Iwata and Y. Takahashi and Yuzuru Iwai and Ruiko Oiwa and Satoshi Ōmura},
  journal={The Journal of antibiotics},
  volume={39 9},
A new antibiotic, lustromycin, was isolated from the cultured broth of Streptomyces sp. SK-1071. It exhibits selective antibacterial activity against anaerobic bacteria including Clostridium sp. The molecular formula C32H38O13 as determined by high resolution mass spectrometry, and elemental analysis and the NMR spectrum suggest structural resemblance of this antibiotic to luminamicin, an anti-anaerobic antibiotic reported previously. 
17 Citations
Coloradocin, an antibiotic from a new Actinoplanes. I. Taxonomy, fermentation and biological properties.
Coloradocin was discovered in a screen for anti-anaerobe activity. The producing organism was determined to be a new species of Actinoplanes, designated Actinoplanes coloradoensis sp. nov.
Isolation and characterization of agglomerins A, B, C and D.
New antibiotics, agglomerins A, B, C and D, were isolated from the culture broth of a bacterial strain identified as Enterobacter agglomersans and are active against a wide variety of anaerobic bacteria and weakly against aerobic Gram-positive bacteria in vitro.
Structures of agglomerins.
Structures of a series of new antibiotics, agglomerins A, B, C and D, which are active against a variety of anaerobic bacteria, were determined to be 1-acyl-2,3-dihydroxy-1,3-butadiene-1-carboxylic
Detection of novel secondary metabolites.
This review focuses on the genesis and development of the gamut of methodologies that have led to the successful detection of the wide variety of novel secondary metabolites that include antibacterial, antigungal, antiviral and antitumour antibiotics, enzyme inhibitors, pharmacologically and immunologically active agents, products useful in agriculture and animal husbandry, microbial regulators, and other compounds for which no bioactive role has yet been found.
Biosynthesis and Ether-Bridge Formation in Nargenicin Macrolides.
The nargenicin biosynthetic locus was identified from a human pathogenic Nocardia arthritidis isolate and a putative iron-α-ketoglutarate-dependent dioxygenase was found to be responsible for the formation of the ether bridge from the newly identified deoxygenated precursor, 8,13-deoxynargenicIn.
The nargenicin family of oxa-bridged macrolide antibiotics.
The history of this family of compounds is reviewed, including synthetic approaches, and the recently uncovered genetic basis for nargenicin production is highlighted, and structure-activity relationships among these molecules are investigated with a view to the future development of members of this unusual antibiotic family.
Toward the total synthesis of Luminamicin: construction of 14-membered lactone framework possessing versatile enol ether moiety
Luminamicin (1) was found to exhibit selective antibacterial activity against anaerobic bacteria by our group in 1985. The concise structure of 14-membered lactone of 1 was synthesized. Construction
Stereostructure of luminamicin, an anaerobic antibiotic, via molecular dynamics, NMR spectroscopy, and the modified Mosher method.
  • H. Gouda, T. Sunazuka, +5 authors S. Ōmura
  • Chemistry, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 2005
The absolute stereostructure of luminamicin, an anaerobic antibiotic, has been determined by using conformational analysis via high-temperature molecular dynamics, NMR spectroscopy, and the modified
The Chemistry of the Nargenicin Macrolides
Publisher Summary The search for natural products possessing antibiotic activity against drug-resistant microorganisms continues to uncover a fascinating array of biologically active compounds. The
Search for new compounds from Kitasato microbial library by physicochemical screening
The Kitasato microbial library and the new compounds discovered from the library by PC screening are introduced and many new compounds were identified among the secondary metabolites of fresh isolated rare actinomycetes and Streptomyces spp.


Luminamicin, a new antibiotic. Production, isolation and physico-chemical and biological properties.
A new antibiotic, luminamicin, was isolated from the culture broth of an actinomycete strain OMR-59. It exhibits antibacterial activity against anaerobic bacteria, especially against Clostridium sp.
Thiotetromycin, a new antibiotic. Taxonomy, production, isolation, and physicochemical and biological properties.
A new antibiotic, thiotetromycin, has been isolated from the culture filtrate of Streptomyces sp. OM-674 by solvent extraction and silica gel chromatography. The molecular formula of the antibiotic
Clostomicins, new antibiotics produced by Micromonospora echinospora subsp. armeniaca subsp. nov. I. Production, isolation, and physico-chemical and biological properties.
A soil isolate named as KMR-593 was found to produce at least five related antibiotics, clostomicins, active against Gram-positive bacteria including anaerobes, and one of these components was identified with lipiarmycin and others were found to be new antibiotics.
Methods for characterization of Streptomyces species
The methods used by collaborators in the ISP for emendation of descriptions of type and neotype strains of the genus Streptomyces (Actinomycetales) are presented.