Lustromycin, a new antibiotic produced by Streptomyces sp.

@article{Tomoda1986LustromycinAN,
  title={Lustromycin, a new antibiotic produced by Streptomyces sp.},
  author={Hiroshi Tomoda and R Iwata and Y. Takahashi and Yuzuru Iwai and Ruiko Oiwa and Satoshi Ōmura},
  journal={The Journal of antibiotics},
  year={1986},
  volume={39 9},
  pages={
          1205-10
        }
}
A new antibiotic, lustromycin, was isolated from the cultured broth of Streptomyces sp. SK-1071. It exhibits selective antibacterial activity against anaerobic bacteria including Clostridium sp. The molecular formula C32H38O13 as determined by high resolution mass spectrometry, and elemental analysis and the NMR spectrum suggest structural resemblance of this antibiotic to luminamicin, an anti-anaerobic antibiotic reported previously. 
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    Proceedings of the National Academy of Sciences of the United States of America
  • 2005
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References

SHOWING 1-4 OF 4 REFERENCES
Luminamicin, a new antibiotic. Production, isolation and physico-chemical and biological properties.
A new antibiotic, luminamicin, was isolated from the culture broth of an actinomycete strain OMR-59. It exhibits antibacterial activity against anaerobic bacteria, especially against Clostridium sp.
Thiotetromycin, a new antibiotic. Taxonomy, production, isolation, and physicochemical and biological properties.
A new antibiotic, thiotetromycin, has been isolated from the culture filtrate of Streptomyces sp. OM-674 by solvent extraction and silica gel chromatography. The molecular formula of the antibiotic
Clostomicins, new antibiotics produced by Micromonospora echinospora subsp. armeniaca subsp. nov. I. Production, isolation, and physico-chemical and biological properties.
TLDR
A soil isolate named as KMR-593 was found to produce at least five related antibiotics, clostomicins, active against Gram-positive bacteria including anaerobes, and one of these components was identified with lipiarmycin and others were found to be new antibiotics.
Methods for characterization of Streptomyces species
TLDR
The methods used by collaborators in the ISP for emendation of descriptions of type and neotype strains of the genus Streptomyces (Actinomycetales) are presented.