Luria-Delbrück fluctuation experiments; accounting simultaneously for plating efficiency and differential growth rate.

@article{Jones1994LuriaDelbrckFE,
  title={Luria-Delbr{\"u}ck fluctuation experiments; accounting simultaneously for plating efficiency and differential growth rate.},
  author={M. E. Jones},
  journal={Journal of theoretical biology},
  year={1994},
  volume={166 3},
  pages={355-63}
}
  • M. E. Jones
  • Published 1994 in Journal of theoretical biology
Cells growing in culture are subject to mutation, and as mutation is a random event, the number of mutants in a culture will be a random variable. The size of the clone of mutants arising from a single mutational event depends on the timing of the mutation; the earlier the mutation the larger the corresponding clone of mutants. The frequency with which new mutations arise may be estimated from examining the number of mutants found in a number of parallel cultures, each culture arising from a… CONTINUE READING