Lupus nephritis: enigmas, conflicting models and an emerging concept.

Abstract

Autoantibodies to components of chromatin, which include double-stranded DNA (dsDNA), histones and nucleosomes, are central in the pathogenesis of lupus nephritis. How anti-chromatin autoantibodies exert their nephritogenic activity, however, is controversial. One model assumes that autoantibodies initiate inflammation when they cross-react with intrinsic… (More)
DOI: 10.2119/molmed.2013.00010

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