Lupus erythematosus (LE) factors recognize both nucleosomes and viable human leucocytes.

@article{Rekvig1981LupusE,
  title={Lupus erythematosus (LE) factors recognize both nucleosomes and viable human leucocytes.},
  author={Ole Petter Rekvig and Kristian Hannestad},
  journal={Scandinavian journal of immunology},
  year={1981},
  volume={13 6},
  pages={597-604}
}
The morphological LE test was completely inhibited by mixing LE-factor-positive sera with core mononucleosomes, the basic histone-DNA subunit of chromatin. Free DNA and free histones at physiological ionic strength were not inhibitory. The LE-factor-binding antigen was virtually completely regained by mixing DNA and the inner histones H2A, H2B, H3 and H4 in… CONTINUE READING