Lupus autoantibodies target ribosomal P proteins

  title={Lupus autoantibodies target ribosomal P proteins},
  author={Keith B Elkon and A P Parnassa and C L Foster},
  journal={The Journal of Experimental Medicine},
  pages={459 - 471}
All nine SLE (systemic lupus erythematosus) sera with antiribosomal antibody activity targeted the same three ribosomal protein antigens, of molecular masses 38 and 17/19 kD when analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blotting. One serum reacted with an additional protein of approximately kD. Ribosomal subunit fractionation by composite gel electrophoresis and sucrose density ultracentrifugation showed that these proteins were part of the large subunit… CONTINUE READING


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