Lupin Allergy: Uncovering Structural Features and Epitopes of β-conglutin Proteins in Lupinus Angustifolius L. with a Focus on Cross-allergenic Reactivity to Peanut and Other Legumes

@inproceedings{JimenezLopez2015LupinAU,
  title={Lupin Allergy: Uncovering Structural Features and Epitopes of $\beta$-conglutin Proteins in Lupinus Angustifolius L. with a Focus on Cross-allergenic Reactivity to Peanut and Other Legumes},
  author={Jos{\'e} Carlos Jimenez-Lopez and Elena Lima-Cabello and Su Melser and Rhonda C. Foley and Karam B. Singh and Juan de Dios Alch{\'e}},
  booktitle={IWBBIO},
  year={2015}
}
The use of sweet lupins as a new food is resulting in an increasing number of cases of allergy reactions, particularly in atopic patients with other pre-existing legume allergies. We performed an extensive in silico analysis of seed β-conglutins, a new family of major allergen proteins in lupin, and a comparison to other relevant food allergens such as Ara h 1. We analyzed surface residues involved in conformational epitopes, lineal B- and T-cell epitopes variability, and changes in 2-D… 
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Narrow Leafed Lupin Beta-Conglutin Proteins Epitopes Identification and Molecular Features Analysis Involved in Cross-Allergenicity to Peanut and Other Legumes
TLDR
Results revealed that considerable structural differences exist, particularly affecting 2-D elements (loops and coils), and numerous micro-heterogeneities are present in fundamental residues directly involved in epitopes differential variability, suggesting variability of residues involved in IgE-binding epitopes might be a major contributor to the observed differences in cross-allergenicity among legumes.
Characterization of narrow-leaf lupin (Lupinus angustifolius L.) recombinant major allergen IgE-binding proteins and the natural β-conglutin counterparts in sweet lupin seed species.
Narrow-Leafed Lupin Main Allergen β-Conglutin (Lup an 1) Detection and Quantification Assessment in Natural and Processed Foods
TLDR
This study demonstrated that this new ELISA method constitutes a highly sensitive and reliable molecular tool able to detect, identify and quantify Lup an 1.
Lupine allergens: Clinical relevance, molecular characterization, cross-reactivity, and detection strategies.
TLDR
In this review, different aspects related with lupine allergy are described, namely, the overall prevalence, clinical relevance, diagnosis, and treatment, as well as the characterization of l upine allergens and their potential cross-reactivity with other legumes are critically discussed.
Bioactive Peptides from Lupinus spp. Seed Proteins-State-of-the-Art and Perspectives
TLDR
This review aims to discuss the current knowledge on lupin protein and their bioactive peptides, highlighting the documented health claims, but also the possibility of allergenicity and the work to be done for the development of new functional products.
Narrow-Leafed Lupin (Lupinus angustifolius) β1- and β6-Conglutin Proteins Exhibit Antifungal Activity, Protecting Plants against Necrotrophic Pathogen Induced Damage from Sclerotinia sclerotiorum and Phytophthora nicotianae
TLDR
It was demonstrated that recombinant purified 6xHis-tagged β1- and β6-conglutin proteins exhibited the strongest in vitro growth inhibitory activity against a range of necrotrophic fungal pathogens compared to β2, β3, and β4 conglutins.
Narrow‐leafed lupin (Lupinus angustifolius L.) β‐conglutin: A multifunctional family of proteins with roles in plant defence, human health benefits, and potential uses as functional food
TLDR
Newly discovered knowledge of the narrow‐leafed lupin β‐conglutin proteins is outlined drawing on information gained from structure‐functional properties, agriculture benefits, as well as nutraceutics and molecular allergy point of views.
In silico assessment of plant L-asparaginase and estimating its allergenicity in comparison to bacteria asparaginase
TLDR
Evidence is provided suggesting the potential utilization of Phaseolus vulgaris asparaginase, which has less epitopes, better predicting tool scores and high similarity, in drug design as an enzymetherapy in leukemia and other cancers.
Narrow‐leafed lupin (Lupinus angustifolius L.) β‐conglutin proteins modulate the insulin signaling pathway as potential type 2 diabetes treatment and inflammatory‐related disease amelioration
TLDR
The results raise the possibility of using these particular β‐conglutin proteins in the prevention and treatment of diabetes, as well as their potential as anti‐inflammatory molecules.
An update on lupin crops and their potential
In this issue focus on efforts and white lupin Australia Europe and highlight the current genetic and genomic resources developed for these species. The genetic diversity of the Lupinus species is…
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