Lupeol suppresses cisplatin-induced nuclear factor-kappaB activation in head and neck squamous cell carcinoma and inhibits local invasion and nodal metastasis in an orthotopic nude mouse model.

@article{Lee2007LupeolSC,
  title={Lupeol suppresses cisplatin-induced nuclear factor-kappaB activation in head and neck squamous cell carcinoma and inhibits local invasion and nodal metastasis in an orthotopic nude mouse model.},
  author={Terence Kin-Wah Lee and Ronnie Tung-ping Poon and Jana Yim-Hung Wo and Stephanie Ma and Xinyuan Guan and Jeffrey N. Myers and Peter Altevogt and Anthony Yuen},
  journal={Cancer research},
  year={2007},
  volume={67 18},
  pages={
          8800-9
        }
}
A poor prognosis in head and neck squamous cell carcinoma (HNSCC) patients is commonly associated with the presence of regional metastasis. Cisplatin-based chemotherapy concurrent with radiation therapy is commonly used in the treatment of locally advanced HNSCC. However, the result is dismal due to common acquisition of chemoresistance and radioresistance. Epidemiologic studies have shown the importance of dietary substances in the prevention of HNSCC. Here, we found that lupeol, a triterpene… CONTINUE READING
Highly Cited
This paper has 115 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 56 extracted citations

Cancer and Chemoprevention: An Overview

Springer Singapore • 2017
View 7 Excerpts
Highly Influenced

Role of the EZH2/miR-200 axis in STAT3-mediated OSCC invasion

International journal of oncology • 2018
View 1 Excerpt

115 Citations

01020'10'13'16'19
Citations per Year
Semantic Scholar estimates that this publication has 115 citations based on the available data.

See our FAQ for additional information.