Corpus ID: 96459910

Lupeol as anti-inflammatory compound tested on Balb / c-TPA Model

  title={Lupeol as anti-inflammatory compound tested on Balb / c-TPA Model},
  author={Lavinia Redeş Crăciun and Daniela Ionescu and Adriana Kaycsa and Sorina Ciurlea and Florin Borcan and Bogdan Petru Radoi and Iuliana Popovici},
Lupeol, a pentacyclic triterpene present in many vegetable structures, is a biologically active compound that has been reported to possess a number of pharmacological properties in the in vivo and in vitro studies. In this study, we investigated the antiinflammatory activities of lupeol on 12-O-tetradecanoylphorbol-13acetate (TPA) induced inflammatory processes on mouse model skin and ear. The inflammation evolution was tested using Mexameter, Tewameter and skin pH-meter and by histological… Expand

Figures from this paper


Anti-inflammatory activity of lupeol and lupeol linoleate in rats.
The results suggest that the mechanism of action of triterpenes is different from the non-steroidal anti-inflammatory drug, indomethacin. Expand
Investigations on the steroidal anti-inflammatory activity of triterpenoids from Diospyros leucomelas.
Three triterpenes were isolated from Diospyros leucomelas and identified as betulin, betulinic acid, and ursolic acid. They showed anti-inflammatory activity in the carrageenan and serotonin pawExpand
A novel derivative pentacyclic triterpene and omega 3 fatty acid.
The increased activities of lysosomal enzymes and glycoproteins associated with decreased collagen in arthritic animals were significantly altered to nearly that of controls. Expand
Anti-inflammatory effect of Pimenta racemosa var. ozua and isolation of the triterpene lupeol.
Results show that the methanol extract from the leaves of Pimenta racemosa var. Expand
Anti-allergic and anti-inflammatory triterpenes from the herb of Prunella vulgaris.
The activity-guided fractionation of the extract of the herb of Prunella vulgaris (Labiatae) led to the isolation of four triterpenes, i.e., betulinic acid, ursolic acid, 2 alpha,3 alpha-dihydroxyurs-12-en-28-oic Acid, and 2 alpha-hydroxyursolic Acid, which exhibited strong inhibitory activities. Expand
Beneficial health effects of lupeol triterpene: a review of preclinical studies.
This minireview discusses in detail the preclinical studies conducted with lupeol and provides an insight into its mechanisms of action. Expand
Effect of lupeol and lupeol linoleate on lysosomal enzymes and collagen in adjuvant-induced arthritis in rats
The level of collagen was significantly decreased and the excretion of urinary hydroxyproline, hexosamine, hexuronic acid and glycosaminoglycans were increased in arthritic rats. Expand
New insights into the mechanism of action of the anti‐inflammatory triterpene lupeol
It is demonstrated that lupeol possessed anti‐inflammatory activity which was likely to depend on its ability to prevent the production of some pro‐inflammatory mediators. Expand
Anti-oxidative and anti-inflammatory activities of some isolated constituents from the stem bark of Allanblackia monticola Staner L.C (Guttiferae)
Methylene chloride fraction of Allanblackia monticola and some derivatives, have antioxidant and anti-inflammatory activities. Expand
Lupeol is the cytotoxic principle in the leaf extract of Dendropanax cf. querceti.
The crude ethanol extract from the leaves of Dendropanax cf. querceti (Araliaceae) from Monteverde, Costa Rica, exhibits cytotoxic activity against Hep-G2, A-431, and H-4IIE tumor cell lines. TheExpand