Lungs of patients with idiopathic pulmonary alveolar proteinosis express a factor which neutralizes granulocyte-macrophage colony stimulating factor.

@article{Tanaka1999LungsOP,
  title={Lungs of patients with idiopathic pulmonary alveolar proteinosis express a factor which neutralizes granulocyte-macrophage colony stimulating factor.},
  author={Naohiko Tanaka and Junko Watanabe and Toshinori Kitamura and Yasukazu Yamada and Shiro Kanegasaki and Koh Nakata},
  journal={FEBS letters},
  year={1999},
  volume={442 2-3},
  pages={246-50}
}
Mice deficient in granulocyte-macrophage colony stimulating factor (GM-CSF) develop pulmonary alveolar proteinosis (PAP). We found that bronchoalveolar lavage fluid (BALF) from 11 patients with idiopathic pulmonary alveolar proteinosis (IPAP) suppressed the growth of peripheral blood monocytes and TF-1 cells, a cell line dependent on either GM-CSF or interleukin-3 (IL-3). The inhibitory effect of PAP-BALF occurred only when TF-1 cells were cultured with GM-CSF but not when cultured with IL-3… CONTINUE READING

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