Lung tumor response in strain A mice as a quantitative bioassay of carcinogenic activity of some carbamates and aziridines.

@article{Shimkin1969LungTR,
  title={Lung tumor response in strain A mice as a quantitative bioassay of carcinogenic activity of some carbamates and aziridines.},
  author={Michael B Shimkin and R. Kelman Wieder and Marita McDonough and L A Fishbeĭn and D Swern},
  journal={Cancer research},
  year={1969},
  volume={29 12},
  pages={2184-90}
}
A'séfiesof 21 carbamates and 8 aziridines were compared for quantitative carcinogenic activity using the pulmonary tumorinduction method in Strain A mice foi bîoassay. Aziridines as a class were more active than the carbamates, with 3,4-dichlorophertyl-jV-carbamoylaziridine being over 20 times more active on a molecular dose basis than urethan, the most active of the carbamates. Three carbamates (jV-hydroxy ethyl, vV-cyanoacetyl ethyl, and ./V-acetyl ethyl) approached the activity, of ethyl… CONTINUE READING

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