Lung tumor development in mice exposed to tobacco smoke and fed beta-carotene diets.

@article{ObermuellerJevic2002LungTD,
  title={Lung tumor development in mice exposed to tobacco smoke and fed beta-carotene diets.},
  author={Ute C. Obermueller-Jevic and Imelda Espiritu and Ana M. Corbacho and Carroll E. Cross and Hanspeter R. Witschi},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2002},
  volume={69 1},
  pages={23-9}
}
In human clinical trials it was found that the putative chemopreventive agent beta-carotene not only failed to protect active smokers against the carcinogenic action of tobacco smoke, but actually increased their risk of developing lung cancer. In preclinical animal studies, beta-carotene had been effective against some chemically induced cancers, but not against tumors in the respiratory tract. We exposed male strain A/J mice to tobacco smoke at a concentration of 140 mg/m(3) of total… CONTINUE READING

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