Lung tumor-associated osteoblast-derived bone morphogenetic protein-2 increased epithelial-to-mesenchymal transition of cancer by Runx2/Snail signaling pathway.

@article{Hsu2011LungTO,
  title={Lung tumor-associated osteoblast-derived bone morphogenetic protein-2 increased epithelial-to-mesenchymal transition of cancer by Runx2/Snail signaling pathway.},
  author={Y L Hsu and M W Huang and Chih-Jen Yang and J B Hung and Ling-Yu Wu and Po-Lin Kuo},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 43},
  pages={37335-46}
}
Bone is a frequent target of lung cancer metastasis and is associated with significant morbidity and a dismal prognosis. Interaction between cancer cells and the bone microenvironment causes a vicious cycle of tumor progression and bone destruction. This study analyzed the soluble factors secreted by lung tumor-associated osteoblast (TAOB), which are responsible for increasing cancer progression. The addition of bone morphogenetic protein-2 (BMP-2), present in large amounts in TAOB conditioned… CONTINUE READING
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BMP-2 Involved in Cancer and Osteoblast Interaction 37346 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

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