Lung transplantation: Mycobacterium abscessus as a cause of graft dysfunction

@article{Cern2007LungTM,
  title={Lung transplantation: Mycobacterium abscessus as a cause of graft dysfunction},
  author={Jos{\'e} J. Cer{\'o}n and Amparo Pastor and Ampar{\'o} Sol{\'e} and Carlos Jord{\'a} and Juan Escriv{\'a} and J. Padilla},
  journal={Breathe},
  year={2007},
  volume={3},
  pages={291 - 296}
}
Lung transplantation (LT) is a therapeutic option in patients with end-stage lung diseases where other effective treatments are lacking [1]. However, the procedure is not without risks and side-effects. One of the most important causes of morbidity and mortality in these patients is infection [1, 2]. Recently, there has been an increase in the incidence of emerging infections, with the majority of mycobacterial infections due to Mycobacterium tuberculosis [3], although this is not the only… 
1 Citations
Tissue-localized immune responses in people with cystic fibrosis and respiratory nontuberculous mycobacteria infection.
TLDR
Lung lobe-specific immune profiles of three cohorts found that CF-NTMPOS airways are distinguished by a hyper-inflammatory cytokine profile, which was dominated by B cells, classical macrophages and the cytokines which support their accumulation.

References

SHOWING 1-10 OF 22 REFERENCES
The spectrum of mycobacterial infection after lung transplantation.
TLDR
It is concluded that mycobacterial infection, particularly due to nontuberculousmycobacteria, is relatively common after lung transplantation and may be an unrecognized cause of graft dysfunction.
Mycobacterium abscessus empyema in a lung transplant recipient.
Tuberculosis in transplanted lungs.
Over a 4-year period in four of 61 patients (6.5%) who survived lung transplantation, pulmonary tuberculosis developed at a mean of 7.5 months (range 3 to 13 months) after operation. Clinical and
Non-tuberculous mycobacteria in end stage cystic fibrosis: implications for lung transplantation
TLDR
The isolation of NTM before transplantation in CF patients should not be an exclusion criterion for lung transplantation, but it may alert the clinician to patients at risk of recurrence following transplantation.
Fatal Pulmonary Infection Due to Multidrug-Resistant Mycobacterium abscessus in a Patient with Cystic Fibrosis
ABSTRACT We report a case of fatal pulmonary infection caused byMycobacterium abscessus in a young patient with cystic fibrosis, who underwent bipulmonary transplantation after a 1-year history of
Mycobacterium abscessus and Other Nontuberculous Mycobacteria: Evolving Respiratory Pathogens in Cystic Fibrosis: A Case Report and Review
  • D. Hayes
  • Medicine, Biology
    Southern medical journal
  • 2005
TLDR
A 14-year-old asymptomatic female patient with CF with minimal bronchiectasis on high-resolution computed tomography scan of the chest who clinically deteriorated over the next 29 months after acquiring Mycobacterium abscessus to the point of being listed for lung transplantation is described.
Infections due to nontuberculous mycobacteria in kidney, heart, and liver transplant recipients.
TLDR
Treatment of NTM infection most commonly involves surgery, reduction in doses of immunosuppressive medications, and/or therapy with antimycobacterial medications; these treatments are often associated with a good outcome.
Mycobacterium abscessus infection in cystic fibrosis. Colonization or infection?
TLDR
Early consideration of treatment for this infection should occur in any patient with cystic fibrosis in whom there is an unexplained deterioration in lung function, and the recent introduction of high dose ibuprofen raises concerns about its possible contribution to the progression of the infection.
Post-transplant bronchiolitis obliterans
TLDR
The alloimmune-dependent and -independent risk factors for bronchiolitis obliterans, the current understanding of the pathogenesis, the clinical staging of the complication, strategies that may contribute to the prevention and/or early detection of bronchiac disease, and suggestions for future research are discussed.
Mycobacterium chelonae/abscessus complex infection in a liver transplant patient
A 25‐year‐old woman presented in October 1999 with fever, nausea, vomiting, and a nodular eruption that had developed over the previous 7 days. Her past medical history was significant for chronic
...
...