Lung surfactant and pulmonary toxicology

  title={Lung surfactant and pulmonary toxicology},
  author={Henk P Haagsman and Lambert M. G. van Golde},
Pulmonary surfactant is essential for a proper functioning of the mammalian lung. It provides mechanical stability to the alveoli, prevents alveolar edema, and plays a role in the pulmonary defense system. Because of this vital role, alterations in the surfactant system may account for some of the observed toxic effects of environmental agents and drugs on the lung. In this review we will discuss the effects of several noxious agents such as oxidant gases, smoke, dusts, and herbicides on the… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 13 extracted citations


Publications referenced by this paper.
Showing 1-10 of 136 references

Effect of ozone on the synthesis of surfactant lipids by isolated alveolar Type II cells

  • HP Haagsman, Schuurmans EAJM, GM Alink, JJ Batenburg, Van Golde LMG
  • Prog Respir Res
  • 1985

A comparison of biochemical effects of nitrogen dioxide , ozone and their combination in mouse lung

  • MG Mustafa, NM Elsayed, +5 authors DE Gardner
  • Toxicol Appl Pharmacol
  • 1984

An assessment of animal models for testing the effect of photochemical oxidants on pulmonary susceptibility to bacterial infection

  • NJ Gross, DM Smith
  • J Toxicol Environ Health
  • 1984

Biosynthesis and secretion of pulmonary surfactant

  • JJ Batenburg
  • JJ (eds) Pulmonary surfactant. Elsevier, Ams…
  • 1984

Catabolism of pulmonary surfactant

  • A Johansson, T Curstedt, B Robertson, P Camner
  • 1984

Similar Papers

Loading similar papers…