Lung stress, strain, and energy load: engineering concepts to understand the mechanism of ventilator-induced lung injury (VILI)

@inproceedings{Nieman2016LungSS,
  title={Lung stress, strain, and energy load: engineering concepts to understand the mechanism of ventilator-induced lung injury (VILI)},
  author={Gary F. Nieman and Joshua Satalin and Philip Lawrence Andrews and Nader M. Habashi and Louis Albert Gatto},
  booktitle={Intensive care medicine experimental},
  year={2016}
}
It was recently shown that acute respiratory distress syndrome (ARDS) mortality has not been reduced in over 15 years and remains ~40 %, even with protective low tidal volume (LVt) ventilation. Thus, there is a critical need to develop novel ventilation strategies that will protect the lung and reduce ARDS mortality. Protti et al. have begun to analyze the impact of mechanical ventilation on lung tissue using engineering methods in normal pigs ventilated for 54 h. They used these methods to… CONTINUE READING
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