Lung-specific RNA interference of coupling factor 6, a novel peptide, attenuates pulmonary arterial hypertension in rats

  title={Lung-specific RNA interference of coupling factor 6, a novel peptide, attenuates pulmonary arterial hypertension in rats},
  author={Jie Yin and Shuling You and N. Li and Shouhai Jiao and Hesheng Hu and Mei Xue and Ye Wang and Wen-juan Cheng and Ju Liu and M. Xu and Suhua Yan and Xiaolu Li},
  journal={Respiratory Research},
BackgroundPulmonary arterial hypertension (PAH) is a progressive and life-threatening disease associated with high morbidity and mortality rates. However, the exact regulatory mechanism of PAH is unknown. Although coupling factor 6 (CF6) is known to function as a repressor, its role in PAH has not been explored. Here, we investigated the involvement of endogenous CF6 in the development of PAH.MethodsPAH was induced with monocrotaline (MCT), as demonstrated by significant increases in pulmonary… Expand
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