Lung-selective gene responses to alveolar hypoxia: potential role for the bone morphogenetic antagonist gremlin in pulmonary hypertension.

@article{Costello2008LungselectiveGR,
  title={Lung-selective gene responses to alveolar hypoxia: potential role for the bone morphogenetic antagonist gremlin in pulmonary hypertension.},
  author={Christine M. Costello and K B Howell and Edwina Cahill and Jean McBryan and Melanie Konigshoff and Oliver Eickelberg and Sean Patrick Gaine and Finian M Martin and Paul McLoughlin},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2008},
  volume={295 2},
  pages={L272-84}
}
Pulmonary hypoxia is a common complication of chronic lung diseases leading to the development of pulmonary hypertension. The underlying sustained increase in vascular resistance in hypoxia is a response unique to the lung. Thus we hypothesized that there are genes for which expression is altered selectively in the lung in response to alveolar hypoxia. Using a novel subtractive array strategy, we compared gene responses to hypoxia in primary human pulmonary microvascular endothelial cells… CONTINUE READING
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