Lung retinol storing cells synthesize and secrete retinoic acid, an inducer of alveolus formation.

@article{Dirami2004LungRS,
  title={Lung retinol storing cells synthesize and secrete retinoic acid, an inducer of alveolus formation.},
  author={Ghenima Dirami and Gloria Decarlo Massaro and Linda B. Clerch and Una S. Ryan and Peter R. Reczek and Donald Massaro},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2004},
  volume={286 2},
  pages={
          L249-56
        }
}
Retinoids play a key role in the formation of pulmonary alveoli. Lipid interstitial cells (LICs) of the alveolar wall store retinol and are concentrated at sites of alveolus formation, suggesting they are an endogenous source of retinoids for alveolus formation. We show in cultured rat lung cells that LICs synthesize and secrete all-trans retinoic acid (ATRA); its secretion is halved by dexamethasone, an inhibitor of alveolus formation. In a second alveolar wall cell, the pulmonary… CONTINUE READING

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