Lung-resistance-related protein expression is a negative predictive factor for response to conventional low but not to intensified dose alkylating chemotherapy in multiple myeloma.

@article{Raaijmakers1998LungresistancerelatedPE,
  title={Lung-resistance-related protein expression is a negative predictive factor for response to conventional low but not to intensified dose alkylating chemotherapy in multiple myeloma.},
  author={H G P Raaijmakers and Miguel Angel Izquierdo and Henk M. Lokhorst and C A de Leeuw and Jeroen A. M. Belien and Andries C. Bloem and Adriaan W Dekker and Rik J. Scheper and P. Sonneveld},
  journal={Blood},
  year={1998},
  volume={91 3},
  pages={1029-36}
}
This study was undertaken to assess the significance of lung-resistance related protein (LRP) expression in plasma cells from untreated multiple myeloma (MM) patients and to determine whether LRP was associated with a poor response and survival in patients treated with different dose regimens of melphalan. Seventy untreated patients received conventional oral dose melphalan (0.25 mg/kg, day 1 to 4) combined with prednisone (MP) or intravenous intermediate-IDM; 70 mg/m2) or high- (140 mg/m2… CONTINUE READING
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