Lung remodeling and pulmonary hypertension after myocardial infarction: pathogenic role of reduced caveolin expression.

@article{Jasmin2004LungRA,
  title={Lung remodeling and pulmonary hypertension after myocardial infarction: pathogenic role of reduced caveolin expression.},
  author={Jean-François Jasmin and Isabelle K Mercier and Robert Hnasko and Michelle W-C Cheung and Herbert B Tanowitz and Jocelyn Dupuis and Michael Phillip Lisanti},
  journal={Cardiovascular research},
  year={2004},
  volume={63 4},
  pages={747-55}
}
OBJECTIVES Pulmonary hypertension (PH) and lung structural remodeling are frequent complications of congestive heart failure (CHF). Yet, the molecular mechanisms involved in CHF-induced PH and lung remodeling remain unknown. Caveolins (Cav-1, -2 and -3) are the principal structural proteins of the vesicular invaginations of the plasma membrane, termed caveolae. Mice with homozygous deletion of the caveolin-1 gene (Cav-1(-/-)) have been shown to develop dilated cardiomyopathy, PH and lung… CONTINUE READING