Lung particle overload: implications for occupational exposures to particles.

@article{Oberdrster1995LungPO,
  title={Lung particle overload: implications for occupational exposures to particles.},
  author={G{\"u}nther Oberd{\"o}rster},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={1995},
  volume={21 1},
  pages={123-35}
}
Chronic pulmonary inflammation, pulmonary fibrosis, and even lung tumors developed in a number of chronic inhalation studies in rats with highly insoluble nonfibrous particles of low cytotoxicity. Concerns were expressed that these responses are due to excessive particulate lung burdens, and the term "particle overload" was coined to characterize these conditions. The hallmark of the particle-overloaded lung is an impairment of alveolar macrophage (AM)-mediated lung clearance which has been… CONTINUE READING
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