Lung opening and closing during ventilation of acute respiratory distress syndrome.

@article{Caironi2010LungOA,
  title={Lung opening and closing during ventilation of acute respiratory distress syndrome.},
  author={Pietro Caironi and Massimo Cressoni and Davide Chiumello and Marco V. Ranieri and Michael Quintel and Sebastiano Russo and Rodrigo R Cornejo and Guillermo Bugedo and Eleonora Carlesso and Riccarda Russo and Luisa Caspani and Luciano Gattinoni},
  journal={American journal of respiratory and critical care medicine},
  year={2010},
  volume={181 6},
  pages={578-86}
}
RATIONALE The effects of high positive end-expiratory pressure (PEEP) strictly depend on lung recruitability, which varies widely during acute respiratory distress syndrome (ARDS). Unfortunately, increasing PEEP may lead to opposing effects on two main factors potentially worsening the lung injury, that is, alveolar strain and intratidal opening and closing, being detrimental (increasing the former) or beneficial (decreasing the latter). OBJECTIVES To investigate how lung recruitability… CONTINUE READING