Lung natural killer cells play a major counter-regulatory role in pulmonary vascular hyperpermeability after myocardial infarction.

@article{Yan2014LungNK,
  title={Lung natural killer cells play a major counter-regulatory role in pulmonary vascular hyperpermeability after myocardial infarction.},
  author={Xiaoxiang Yan and Ahmed E Hegab and Jin Endo and Atsushi Anzai and Tomohiro Matsuhashi and Yoshinori Katsumata and Kentaro Ito and Tsunehisa Yamamoto and Tomoko Betsuyaku and Ken Shinmura and Wei Shen and Eric Vivier and Keiichi Fukuda and Motoaki Sano},
  journal={Circulation research},
  year={2014},
  volume={114 4},
  pages={637-49}
}
RATIONALE Natural killer (NK) cells are lymphocytes of the innate immune system that play specialized and niche-specific roles in distinct organs. OBJECTIVE We investigated the possible function of NK cells in the pathogenesis of congestive heart failure after myocardial infarction. METHODS AND RESULTS Depletion of NK cells from mice had little effect on cytokine expression (tumor necrosis factor-α, interleukin [IL]-6, and IL-1β), neutrophil and macrophage infiltration into infarcted… CONTINUE READING

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