Lung myofibroblasts as targets of salmeterol and fluticasone propionate: inhibition of alpha-SMA and NF-kappaB.

@article{Baouz2005LungMA,
  title={Lung myofibroblasts as targets of salmeterol and fluticasone propionate: inhibition of alpha-SMA and NF-kappaB.},
  author={Soria Baouz and Julien Giron-Michel and Bruno Azzarone and Massimo Giuliani and Francesca Cagnoni and Susanna Leanderson Olsson and Renato Testi and Giulio Gabbiani and Giorgio Walter Canonica},
  journal={International immunology},
  year={2005},
  volume={17 11},
  pages={1473-81}
}
Lung myofibroblasts play a major role in the pathophysiology of asthma, contributing not only to tissue remodelling but also to airway inflammation. Nevertheless, only recently, attention has been focused on these cells as potential targets for anti-allergic drugs. Herein, we analysed the pharmacological response of lung myofibroblasts to beta2-agonists associated or not to inhaled corticosteroids, investigating their effects on (i) the constitutive and transforming growth factor-beta (TGF-beta… CONTINUE READING