Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice.

@article{Bedoret2009LungIM,
  title={Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice.},
  author={Denis Bedoret and Hugues Wallemacq and Thomas Marichal and Christophe J Desmet and Florence Quesada Calvo and Emmanuelle Henry and Rodrigue Closset and Benjamin J. Dewals and Caroline Thielen and Pascal Gustin and Laurence de Leval and Nico Van Rooijen and Ala{\'i}n Le Moine and Alain F C Vanderplasschen and Didier Cataldo and Pierre-Vincent Drion and M. G. Moser and Pierre M Lekeux and Fabrice Bureau},
  journal={The Journal of clinical investigation},
  year={2009},
  volume={119 12},
  pages={3723-38}
}
The respiratory tract is continuously exposed to both innocuous airborne antigens and immunostimulatory molecules of microbial origin, such as LPS. At low concentrations, airborne LPS can induce a lung DC-driven Th2 cell response to harmless inhaled antigens, thereby promoting allergic asthma. However, only a small fraction of people exposed to environmental LPS develop allergic asthma. What prevents most people from mounting a lung DC-driven Th2 response upon exposure to LPS is not understood… CONTINUE READING
Highly Influential
This paper has highly influenced a number of papers. REVIEW HIGHLY INFLUENTIAL CITATIONS