Lung inflammation is associated with reduced pulmonary nucleotide excision repair in vivo.

@article{Gngr2010LungII,
  title={Lung inflammation is associated with reduced pulmonary nucleotide excision repair in vivo.},
  author={Nejla G{\"u}ng{\"o}r and Astrid Haegens and Ad M. Knaapen and Roger W. L. Godschalk and Roland K. Chiu and Emiel F. M. Wouters and Frederik-Jan van Schooten},
  journal={Mutagenesis},
  year={2010},
  volume={25 1},
  pages={77-82}
}
Chronic pulmonary inflammation is associated with increased lung cancer risk, but the underlying process remains unknown. Recently, we showed that activated neutrophils inhibit nucleotide excision repair (NER) in pulmonary epithelial cells in vitro via the release of myeloperoxidase (MPO). To evaluate the effect of neutrophils on NER in vivo, mice were intratracheally instilled with lipopolysaccharide (LPS) (20 microg), causing acute lung inflammation and associated neutrophil influx into the… CONTINUE READING
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