Lung inflammation induced by lipoteichoic acid or lipopolysaccharide in humans.

@article{Hoogerwerf2008LungII,
  title={Lung inflammation induced by lipoteichoic acid or lipopolysaccharide in humans.},
  author={Jacobien J. Hoogerwerf and Alex F. de Vos and Paul Bresser and Jaring S van der Zee and Jennie M. Pater and Anita M Tuip de Boer and Michael W. T. Tanck and Daniel Lundell and Chung Her-Jenh and Christian Draing and Sonja von Aulock and Tom van der Poll},
  journal={American journal of respiratory and critical care medicine},
  year={2008},
  volume={178 1},
  pages={34-41}
}
RATIONALE Recognition of pathogen-associated molecular patterns by Toll-like receptors (TLRs) is considered to be important for an appropriate immune response against pathogens that enter the lower airways. OBJECTIVES We studied the effects of two different TLR agonists relevant for respiratory infections in the human lung: lipoteichoic acid (LTA; TLR2 agonist, component of gram-positive bacteria) and lipopolysaccharide (LPS; TLR4-agonist, component of gram-negative bacteria). METHODS… CONTINUE READING

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