Lung hypoplasia caused by nitrofen is mediated by down-regulation of thyroid transcription factor TTF-1

@article{Losada1999LungHC,
  title={Lung hypoplasia caused by nitrofen is mediated by down-regulation of thyroid transcription factor TTF-1},
  author={Alejandro Losada and Hui-jing Xia and Lucia Migliazza and Juan A. Diez-Pardo and Pilar Santisteban and Juan Antonio Tovar},
  journal={Pediatric Surgery International},
  year={1999},
  volume={15},
  pages={188-191}
}
Prenatal exposure to nitrofen induces lung hypoplasia and diaphragmatic hernias very similar to those in human disease, but the mechanisms are still unknown. Thyroid transcription factor 1 (TTF-1) is involved in lung ontogeny and regulation of the expression of surfactant proteins, and is likely abnormally expressed in nitrofen-induced lung hypoplasia. This study examines the effect of nitrofen on TTF-1 messenger RNA (mRNA) expression in the lungs of prenatal rat fetuses and a human lung-cell… CONTINUE READING
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Transcription of the lung-speci®c surfactant protein C gene is mediated by thyroid transcription factor 1

  • SE Kelly, CJ Bachursky, MS Burhans, SW Glasser
  • J Biol Chem
  • 1996
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