Lung function in survivors of childhood acute lymphoblastic leukemia.

@article{Fulgoni1999LungFI,
  title={Lung function in survivors of childhood acute lymphoblastic leukemia.},
  author={Paola Fulgoni and Maria Cristina Zoia and Angelo Guido Corsico and Massimiliano Beccaria and G Georgiani and Grazia Bossi and Isa Cerveri},
  journal={Chest},
  year={1999},
  volume={116 5},
  pages={
          1163-7
        }
}
STUDY OBJECTIVES To evaluate lung function in patients cured from childhood acute lymphoblastic leukemia (ALL) with chemotherapy alone or plus bone marrow transplantation (BMT). Pulmonary toxicity is a well-recognized side effect of many ALL treatments. DESIGN Cross-sectional study conducted at least 3 years after cessation of therapy. SETTING Outpatient pneumology department of the University Hospital. PATIENTS Forty-four subjects (age range at observation, 6 to 23 years): 21 treated… 
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Pulmonary dysfunction is more evident with combined chemotherapy and radiotherapy, bleomycin, and methotrexate are the most incriminated chemotherapeutic agents, and males are at higher risk than females; therefore a specific and extended follow-up is warranted.
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The aims were to determine the frequency and severity of pulmonary late sequelae among children treated for cancer to identify treatment risk factors and the methods for continued followup.
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A screening for respiratory abnormalities in CLS seems to be of significant importance, and the main symptom of impaired lung diffusion was poor tolerance of exercise, which is the most frequent abnormality in CLS.
[Examination of late pulmonary toxicity in children treated for malignancies].
TLDR
The obstructive pulmonary abnormalities caused by the treatment showed an improving tendency over time, and Restrictive pulmonary disorder was detected in only small part of the treated patients.
Lung function and late pulmonary complications among survivors of hematopoietic stem cell transplantation during childhood.
Pulmonary function impairment measured by pulmonary function tests in long-term survivors of childhood cancer
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The prevalence of pulmonary function impairment in long-term adult CCSs who received potentially pulmotoxic therapy is high and pulmonary radiotherapy, especially in combination with bleomycin or surgery, is the most important risk factor.
Lung function after allogeneic hematopoietic stem cell transplantation in children: a longitudinal study in a population-based cohort.
Risk factors for impaired pulmonary function and cardiorespiratory fitness in very long-term adult survivors of childhood acute lymphoblastic leukemia after treatment with chemotherapy only*
TLDR
Increased attention and targeted advice on modifiable lifestyle factors such as smoking, inactivity and overweight are suggested to preserve pulmonary function and cardiorespiratory fitness in very long-term survivors of childhood ALL.
Clinical Significance of Pulmonary Function Tests in Long-Term Survivors after Myeloablative Allogeneic Hematopoietic Stem Cell Transplantation
TLDR
It is concluded that abnormal lung function before transplantation may be associated with a decline in pulmonary function within 1 year after transplantation, but late-onset noninfectious pulmonary complications could not be predicted from pretransplantation lung function.
Pulmonary Complications of Malignancies and Blood and Marrow Transplantation
TLDR
This chapter provides an overview of respiratory complications of childhood cancer and BMT, with a focus on mechanisms of injury.
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