Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation.

@article{Sorkness2008LungFI,
  title={Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation.},
  author={Ronald L. Sorkness and Eugene Bleecker and William W. Busse and William J. Calhoun and M. Castro and Kian Fan Chung and Douglas Curran-Everett and Serpil C. Erzurum and Benjamin M. Gaston and Nizar N Jarjour and W. C. Moore and Stephen P. Peters and William Gerald Teague and Sally E Wenzel},
  journal={Journal of applied physiology},
  year={2008},
  volume={104 2},
  pages={
          394-403
        }
}
Five to ten percent of asthma cases are poorly controlled chronically and refractory to treatment, and these severe cases account for disproportionate asthma-associated morbidity, mortality, and health care utilization. While persons with severe asthma tend to have more airway obstruction, it is not known whether they represent the severe tail of a unimodal asthma population, or a severe asthma phenotype. We hypothesized that severe asthma has a characteristic physiology of airway obstruction… CONTINUE READING
Highly Cited
This paper has 111 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 59 extracted citations

Techniques of assessing small airways dysfunction

European clinical respiratory journal • 2014
View 15 Excerpts
Highly Influenced

Study of correlation between forced vital capacity and demand for healthcare services in severe asthmatics

Multidisciplinary respiratory medicine • 2015
View 8 Excerpts
Method Support
Highly Influenced

Markers of vascular perturbation correlate with airway structural change in asthma.

American journal of respiratory and critical care medicine • 2013
View 12 Excerpts
Method Support
Highly Influenced

111 Citations

0102030'10'13'16'19
Citations per Year
Semantic Scholar estimates that this publication has 111 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 51 references

Severe asthma: lessons from the Severe Asthma Research Program.

The Journal of allergy and clinical immunology • 2007
View 4 Excerpts
Highly Influenced

The structural basis of airways hyperresponsiveness in asthma.

Journal of applied physiology • 2006
View 7 Excerpts
Highly Influenced

Detection of excessive bronchoconstriction in asthma.

American journal of respiratory and critical care medicine • 1996
View 5 Excerpts
Highly Influenced

Difficult asthma.

Proceedings of the American Thoracic Society • 2006
View 1 Excerpt

Severe asthma: an overview.

The Journal of allergy and clinical immunology • 2006
View 1 Excerpt