Lung fibroblast repair functions in patients with chronic obstructive pulmonary disease are altered by multiple mechanisms.

@article{Togo2008LungFR,
  title={Lung fibroblast repair functions in patients with chronic obstructive pulmonary disease are altered by multiple mechanisms.},
  author={Shinsaku Togo and Olaf Holz and Xiangde D Liu and Hisatoshi Sugiura and Koichiro Kamio and Xiangqi Wang and Shin Kawasaki and Youngsoo Ahn and Karin Fredriksson and C. Magnus Skold and K. M{\"u}ller and Detlef Branscheid and Lutz Welker and Henrik Watz and H. Magnussen and Stephen I. Rennard},
  journal={American journal of respiratory and critical care medicine},
  year={2008},
  volume={178 3},
  pages={248-60}
}
RATIONALE Fibroblasts are believed to be the major cells responsible for the production and maintenance of extracellular matrix. Alterations in fibroblast functional capacity, therefore, could play a role in the pathogenesis of pulmonary emphysema, which is characterized by inadequate maintenance of tissue structure. OBJECTIVES To evaluate the hypothesis that deficient fibroblast repair characterizes cells obtained from individuals with chronic obstructive pulmonary disease (COPD) compared… CONTINUE READING
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Morbidity and mortality: chartbook on cardiovascular, lung and blood disease

  • National Heart, Lung, Blood Institute
  • (accessed January
  • 2006
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