Lung epithelial cell lines in coculture with human pulmonary microvascular endothelial cells: development of an alveolo-capillary barrier in vitro

@article{Hermanns2004LungEC,
  title={Lung epithelial cell lines in coculture with human pulmonary microvascular endothelial cells: development of an alveolo-capillary barrier in vitro},
  author={M. I. Hermanns and R. Unger and K. Kehe and K. Peters and C. Kirkpatrick},
  journal={Laboratory Investigation},
  year={2004},
  volume={84},
  pages={736-752}
}
We have established a coculture system of human distal lung epithelial cells and human microvascular endothelial cells in order to study the cellular interactions of epithelium and endothelium at the alveolocapillary barrier in both pathogenesis and recovery from acute lung injury. The aim was to determine conditions for the development of functional cellular junctions and the formation of a tight epithelial barrier similar to that observed in vivo. The in vitro coculture system consisted of… Expand
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