Lung epithelial CCAAT/enhancer-binding protein-β is necessary for the integrity of inflammatory responses to cigarette smoke.

@article{Didon2011LungEC,
  title={Lung epithelial CCAAT/enhancer-binding protein-β is necessary for the integrity of inflammatory responses to cigarette smoke.},
  author={Lukas Didon and Jenny L. Barton and Abraham B. Roos and Gordon J. Gaschler and Carla M. T. Bauer and Tove Berg and Martin R. St{\"a}mpfli and Magnus Kristofer Nord},
  journal={American journal of respiratory and critical care medicine},
  year={2011},
  volume={184 2},
  pages={
          233-42
        }
}
RATIONALE Cigarette smoke is the major cause of chronic obstructive pulmonary disease and lung cancer. The mechanisms by which smoking induces pulmonary dysfunction are complex, involving stress from toxic components and inflammatory responses. Although CCCAAT/enhancer-binding protein (C/EBP)-β is known as a key intracellular regulator of inflammatory signaling, its role in pulmonary inflammation has not been established. OBJECTIVES To characterize the role of C/EBPβ in the airway epithelial… CONTINUE READING

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