Lung development and function in preterm infants in the surfactant treatment era.

@article{Jobe2000LungDA,
  title={Lung development and function in preterm infants in the surfactant treatment era.},
  author={Alan H. Jobe and Machiko Ikegami},
  journal={Annual review of physiology},
  year={2000},
  volume={62},
  pages={
          825-46
        }
}
Mortality of infants of < 1-kg birth weight has decreased because of surfactant treatments, antenatal glucocorticoid treatments, and new ventilation strategies. However, many of these infants develop a chronic lung disease characterized by an arrest of lung development and interference with alveolarization. Antenatal glucocorticoids can induce early lung maturation clinically, but new information from transgenic and other experimental models indicates that traditional explanations for… CONTINUE READING

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