Lung deposition of inhaled alpha1-proteinase inhibitor in cystic fibrosis and alpha1-antitrypsin deficiency.

@article{Brand2009LungDO,
  title={Lung deposition of inhaled alpha1-proteinase inhibitor in cystic fibrosis and alpha1-antitrypsin deficiency.},
  author={P. A. J. Brand and Martina Schulte and Marion Wencker and Christiane Herpich and Gregory Klein and Kim Hanna and Thomas Meyer},
  journal={The European respiratory journal},
  year={2009},
  volume={34 2},
  pages={354-60}
}
Individuals with alpha(1)-antitrypsin (AAT) deficiency and cystic fibrosis (CF) have a protease-antiprotease imbalance in their lungs, which leads to early onset progressive lung disease. Inhalation of AAT may restore protective levels in the lungs. This study aimed to determine the efficiency of delivering AAT using a novel inhalation device in subjects with AAT deficiency and CF compared with healthy subjects. In total, 20 subjects (six healthy, seven with AAT deficiency and seven with CF… CONTINUE READING