Lung compartmentalization of increased TNF releasing ability by mononuclear phagocytes in pulmonary sarcoidosis.

@article{Spatafora1989LungCO,
  title={Lung compartmentalization of increased TNF releasing ability by mononuclear phagocytes in pulmonary sarcoidosis.},
  author={Mario Spatafora and Anna Maria Merendino and Giuseppina Chiappara and Mark Gjomarkaj and M. D. Miriam Melis and Vincenzo Bellia and Giovanni Bonsignore},
  journal={Chest},
  year={1989},
  volume={96 3},
  pages={542-9}
}
The TNF is a monokine with cytotoxic and tumor-necrosing activities; in addition, TNF may play a role in inflammatory processes. The present study evaluates spontaneous and LPS-mediated release of TNF by AMs and autologous peripheral BMs of normal subjects and patients with pulmonary sarcoidosis. A recently developed cytotoxicity assay, specific for detection of TNF activity, was applied. This study demonstrates that (1) unstimulated mononuclear phagocytes released low levels of TNF with no… CONTINUE READING
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by tumor necrosis factor

  • CA Dinarello, JG Cannon, SM Wolff, HA Bernheim, B Beutler, A Cerami
  • J Immunol
  • 1987

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