Lung carcinogenesis induced by chronic tuberculosis infection: the experimental model and genetic control

@article{Nalbandian2009LungCI,
  title={Lung carcinogenesis induced by chronic tuberculosis infection: the experimental model and genetic control},
  author={Ang{\`e}le Nalbandian and B Yan and Alexander Pichugin and Roderick Terry Bronson and Igor Kramnik},
  journal={Oncogene},
  year={2009},
  volume={28},
  pages={1928-1938}
}
Coexistence of pulmonary tuberculosis (TB) and lung cancer in clinic poses significant challenges for the diagnostic and treatment of both diseases. Although association of chronic inflammation and cancer is well-documented, causal relationship between TB infection and lung cancer are not understood. We present experimental evidence that chronic TB infection induces cell dysplasia and squamous cell carcinoma (SCC) in a lung-specific manner. First, squamous cell aggregates consistently appeared… CONTINUE READING
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