Lung cancer tumorigenicity and drug resistance are maintained through ALDHhiCD44hi tumor initiating cells

@inproceedings{Liu2013LungCT,
  title={Lung cancer tumorigenicity and drug resistance are maintained through ALDHhiCD44hi tumor initiating cells},
  author={Jing Liu and Zhijie Xiao and Sunny Kit-Man Wong and Vicky Pui-Chi Tin and Ka-Yan Ho and Junwen Wang and Mai-Har Sham and Maria Pik Wong},
  booktitle={Oncotarget},
  year={2013}
}
Limited improvement in long term survival of lung cancer patients has been achieved by conventional chemotherapy or targeted therapy. To explore the potentials of tumor initiating cells (TIC)-directed therapy, it is essential to identify the cell targets and understand their maintenance mechanisms. We have analyzed the performance of ALDH/CD44 co-expression as TIC markers and treatment targets of lung cancer using well-validated in vitro and in vivo analyses in multiple established and patient… CONTINUE READING
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