Lung cancer susceptibility locus at 5p15.33.


We carried out a genome-wide association study of lung cancer (3,259 cases and 4,159 controls), followed by replication in 2,899 cases and 5,573 controls. Two uncorrelated disease markers at 5p15.33, rs402710 and rs2736100 were detected by the genome-wide data (P = 2 x 10(-7) and P = 4 x 10(-6)) and replicated by the independent study series (P = 7 x 10(-5) and P = 0.016). The susceptibility region contains two genes, TERT and CLPTM1L, suggesting that one or both may have a role in lung cancer etiology.

DOI: 10.1038/ng.254

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@article{McKay2008LungCS, title={Lung cancer susceptibility locus at 5p15.33.}, author={James McKay and Rayjean J Hung and Val{\'e}rie Gaborieau and Paolo Boffetta and Am{\'e}lie Chabrier and Graham Byrnes and David G. Zaridze and Anush Mukeria and Neonilia Szeszenia-Dabrowska and Jolanta Lissowska and P{\'e}ter Rudnai and Eleon{\'o}ra Fabi{\'a}nov{\'a} and Dana Mateş and Vladim{\'i}r Bencko and Lenka For{\'e}tova and Vladim{\'i}r Janout and John R McLaughlin and Frances A. Shepherd and Alexandre Montpetit and S A Narod and Hans Einar Krokan and Frank Skorpen and Maiken Bratt Elvestad and Lars J Vatten and Inger Nj\olstad and Tomas Andri Axelsson and Chu Chen and Gary E. Goodman and Matt J. Barnett and Melissa M. Loomis and Jan Lubiński and Joanna Matyjasik and Marcin Radosław Lener and Dorota Oszutowska and John K. Field and Triantafillos Liloglou and George E Xinarianos and Adrian Cassidy and Paolo Vineis and Francoise Clavel-Chapelon and Domenico Palli and Rosario Tumino and Vittorio Krogh and Salvatore Panico and Carlos A. Gonz{\'a}lez and Jos{\'e} Ram{\'o}n Quir{\'o}s and Carmen Mart{\'i}nez and Carmen Navarro and Eva Ardanaz and Nerea Larra{\~n}aga Larra{\~n}aga and Kay Tee Kham and Timothy J Key and Hendrik Bas Bueno-de-Mesquita and Petra H. M. Peeters and Antonia Trichopoulou and Jakob P Linseisen and H. Boeing and G{\"{o}ran Hallmans and Kim Overvad and Anne Marie Tj\onneland and Merethe H Kumle and Elio Riboli and Diana Z{\'e}l{\'e}nika and Anne Boland and Marc D{\'e}l{\'e}pine and Mario Foglio and Doris Lechner and Fumihiko Matsuda and H{\'e}l{\`e}ne Blanch{\'e} and Ivo G Gut and Simon Heath and Mark Lathrop and Paul Brennan}, journal={Nature genetics}, year={2008}, volume={40 12}, pages={1404-6} }