Lung cancer risk and CYP1A1 genotype in African Americans.

  title={Lung cancer risk and CYP1A1 genotype in African Americans.},
  author={Emanuela Taioli and Jean G. Ford and Julie D. Trachman and Yanan Li and Rita I. Demopoulos and Seymour J. Garte},
  volume={19 5},
The role of CYP1A1 genotype in lung cancer risk was assessed in African Americans through a case control study. The complete CYP1A1 genotype, including the frequency of all three polymorphisms (Msp1 [CYP1A1*2], exon 7 [CYP1A1*3] and African American specific [CYP1A1*4]) was determined by PCR on 307 controls and 105 cases of lung cancer among African Americans. We have confirmed our earlier observation of a significant increased risk (odds ratio = 2.8, 95% CI = 1.3-6.5) for lung adenocarcinoma… CONTINUE READING


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