Lung and systemic oxidant and antioxidant activity after graded smoke exposure in the rat.

@article{Lalonde1994LungAS,
  title={Lung and systemic oxidant and antioxidant activity after graded smoke exposure in the rat.},
  author={Cheryl Lalonde and Lisa Picard and Catherine N. Campbell and Robert H. Demling},
  journal={Circulatory shock},
  year={1994},
  volume={42 1},
  pages={7-13}
}
We wanted to determine the effect of a graded smoke inhalation on lung and systemic oxidant stress, and its relationship to physiological and histological change. Male Wistar rats were given 12 breaths of 10 ml/kg (n = 8) (group 1) or 20 ml/kg (n = 8) (group 2) tidal volume, using cotton toweling smoke through the trachea using positive pressure. Rats were monitored, then killed at 24 hr. Data were compared to controls (n = 8). Peak group 1 and group 2 carboxyhemoglobins were 22 +/- 6 and 46… CONTINUE READING

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