Lung air spaces: MR imaging evaluation with hyperpolarized 3He gas.

@article{Lange1999LungAS,
  title={Lung air spaces: MR imaging evaluation with hyperpolarized 3He gas.},
  author={Eduard E de Lange and John P. Mugler and James R. Brookeman and Jack Knight-Scott and Jonathon D Truwit and C. David Teates and Thomas M. Daniel and Paul Bogorad and G. D. Cates},
  journal={Radiology},
  year={1999},
  volume={210 3},
  pages={851-7}
}
Thirty-two magnetic resonance imaging examinations of the lungs were performed in 16 subjects after inhalation of 1-2 L of helium 3 gas that was laser polarized to 10%-25%. The distribution of the gas was generally uniform, with visualization of the fissures in most cases. Ventilation defects were demonstrated in smokers and in a subject with allergies. The technique has potential for evaluating small airways disease. 

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