Lung Tumor-associated Osteoblast-derived Bone Morphogenetic Protein-2 Increased Epithelial-to-Mesenchymal Transition of Cancer by Runx2/Snail Signaling Pathway*

@article{Hsu2011LungTO,
  title={Lung Tumor-associated Osteoblast-derived Bone Morphogenetic Protein-2 Increased Epithelial-to-Mesenchymal Transition of Cancer by Runx2/Snail Signaling Pathway*},
  author={Y. Hsu and M. Huang and C. Yang and J. Hung and Ling-Yu Wu and P. Kuo},
  journal={The Journal of Biological Chemistry},
  year={2011},
  volume={286},
  pages={37335 - 37346}
}
  • Y. Hsu, M. Huang, +3 authors P. Kuo
  • Published 2011
  • Medicine, Biology
  • The Journal of Biological Chemistry
  • Bone is a frequent target of lung cancer metastasis and is associated with significant morbidity and a dismal prognosis. Interaction between cancer cells and the bone microenvironment causes a vicious cycle of tumor progression and bone destruction. This study analyzed the soluble factors secreted by lung tumor-associated osteoblast (TAOB), which are responsible for increasing cancer progression. The addition of bone morphogenetic protein-2 (BMP-2), present in large amounts in TAOB conditioned… CONTINUE READING
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