Lung Tumor Development in Mice Exposed to Tobacco Smoke and Fed β-Carotene Diets

@article{ObermuellerJevic2002LungTD,
  title={Lung Tumor Development in Mice Exposed to Tobacco Smoke and Fed β-Carotene Diets},
  author={U. Obermueller-Jevic and I. Espiritu and A. Corbacho and C. Cross and H. Witschi},
  journal={Toxicological Sciences},
  year={2002},
  volume={69},
  pages={23-29}
}
In human clinical trials it was found that the putative chemopreventive agent beta-carotene not only failed to protect active smokers against the carcinogenic action of tobacco smoke, but actually increased their risk of developing lung cancer. In preclinical animal studies, beta-carotene had been effective against some chemically induced cancers, but not against tumors in the respiratory tract. We exposed male strain A/J mice to tobacco smoke at a concentration of 140 mg/m(3) of total… Expand
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