Lung Tumor Development in Mice Exposed to Tobacco Smoke and Fed β-Carotene Diets
@article{ObermuellerJevic2002LungTD, title={Lung Tumor Development in Mice Exposed to Tobacco Smoke and Fed β-Carotene Diets}, author={U. Obermueller-Jevic and I. Espiritu and A. Corbacho and C. Cross and H. Witschi}, journal={Toxicological Sciences}, year={2002}, volume={69}, pages={23-29} }
In human clinical trials it was found that the putative chemopreventive agent beta-carotene not only failed to protect active smokers against the carcinogenic action of tobacco smoke, but actually increased their risk of developing lung cancer. In preclinical animal studies, beta-carotene had been effective against some chemically induced cancers, but not against tumors in the respiratory tract. We exposed male strain A/J mice to tobacco smoke at a concentration of 140 mg/m(3) of total… Expand
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