Lung Pathologies in a Chronic Inflammation Mouse Model Are Independent of Eosinophil Degranulation.

@article{Jacobsen2017LungPI,
  title={Lung Pathologies in a Chronic Inflammation Mouse Model Are Independent of Eosinophil Degranulation.},
  author={Elizabeth A. Jacobsen and Sergei I. Ochkur and Alfred D. Doyle and William E Lesuer and Wen Li and Cheryl A. Protheroe and Dana C. Colbert and Katie R Zellner and HuaHao H Shen and Charles G. Irvin and James Joseph Lee and Nancy A. Lee},
  journal={American journal of respiratory and critical care medicine},
  year={2017},
  volume={195 10},
  pages={1321-1332}
}
RATIONALE The release of eosinophil granule proteins in the lungs of patients with asthma has been dogmatically linked with lung remodeling and airway hyperresponsiveness. However, the demonstrated inability of established mouse models to display the eosinophil degranulation occurring in human subjects has prevented a definitive in vivo test of this hypothesis. OBJECTIVES To demonstrate in vivo causative links between induced pulmonary histopathologies/lung dysfunction and eosinophil… CONTINUE READING
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